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The difference in efficacy between these two doses is modest, but the difference in side effects can be meaningful for some individuals

Patients are ONLY candidates with a BMI of 25 or above, as that is the indication for overweight

GLP-1 Receptor Agonists (e.g., semaglutide, liraglutide) Increase insulin secretion in response to food Reduce glucagon release (which lowers blood sugar) Slows gastric emptying (which helps with post-meal glucose excursions) Reduces appetite and induces satiety which leads to weight loss GLP-1/GIP Receptor Agonists (e.g., tirzepatide) GLP-1 effects (same as above) GIP effect: further enhances insulin secretion Both medications help with blood sugar control and weight loss, but Mounjaros dual mechanism may offer stronger effects on insulin secretion, which improves A1c levels

The STEP trials, focusing on weight management in patients with obesity, similarly reported systolic blood pressure decreases of 48 mmHg with semaglutide 2.4 mg compared to placebo

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